The presence of a warning sign may predict severe dengue in a patient. When … Symptoms typically begin three to fourteen days after infection. Dengue Shock Syndrome (DSS) — Shock syndrome is a dangerous complication of dengue infection and is associated with high mortality. Author Summary Epidemics of dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) are overwhelming public health capacity for diagnosis and patient care. It is a mosquito-borne infection found in tropical and sub-tropical regions around the world[1]. deadly dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) because of the severity of antibody response (Valdes et al., 2000). Dengue shock syndrome is defined as dengue hemorrhagic fever plus: - Weak rapid pulse - Narrow pulse pressure (less than 20 mm Hg) - Cold, clammy skin and restlessness. Consequently, we analyzed the extent to which two blood sources affected life table characteristics (i.e. Severe dengue is a potentially lethal complication of dengue infection. increase the risk of developing severe dengue. The symptoms of dengue hemorrhagic fever can trigger dengue shock syndrome. Dengue fever, also known as breakbone fever, is a vector-borne disease transmitted by the bite of an infected female Aedes mosquito. Their survival is dependent on an animal or insect host, called the reservoir. Supplementary. Dengue virus infects about 50 million people worldwide each year. From 1975 through 2009, symptomatic dengue virus infections were classified according to the WHO guidelines as dengue fever, dengue hemorrhagic fever (DHF), and dengue shock syndrome (the most severe form of … 2004 Jun42(6):2866-9. Author Summary Dengue is the most rapidly spreading mosquito-borne viral disease in the world and approximately 2.5 billion people live in dengue endemic countries. DHF and DSS symptoms include fever; a low platelet count; haemorrhagic bleeding and vascular permeability. 1. Dengue infection begins as a febrile illness; the fever is accompanied by constitutional symptoms and a characteristic flushing of the skin. • Dengue viruses are stable in dried blood and exudates up to several days at room temperature. Serology will reveal a marked increase in immunoglobulins. 10. With consideration of this issue, this research determined the role … Pay particular Dengue Hemorrhagic Fever (DHF) is a severe form of dengue fever (DF), which can be life threatening. Majority of affected people are asymptomatic, and to some extent, mild dengue fever. competence for dengue virus (DENV) is unknown. A total of 90 Dengue patients were included in the study. Crystalloid fluid resuscitation and standard DIC treatment are critical to the child's survival. Dengue hemorrhagic fever: Children less than 15 years are the most common victims. There … Dengue hemorrhagic fever and dengue shock syndrome are distinguished from dengue fever, a less serious affliction, by the release of a storm of molecules, known as cytokines, that send the host immune system into a frenzy. ... had a severe consequence on his chance of survival. Toxic Shock Syndrome Information Service. The distinctive feature of DHF is capillary leakage (pleural effusion, ascites, or hypoproteinemia) accompanied by hemorrhagic manifestations that occur 4-7 days after onset of the disease. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever (DHF), or dengue shock syndrome. Nevertheless, scientists' understanding of dengue virus may be simplistic, as rather than distinct antigenic groups, a continuum appears to exist. albopictus for DENV. Twenty-six of DSS (44.1%) were referred cases and 5 of them died, case fatality rate was 8.8%. Am.J.Trop.Med. In the last 20 years, dengue fever and a severe form of the disease described for the first time in the mid-1950s—dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS)—have emerged as the most important arthropod-borne viral diseases of humans (1–3).During this period the frequency of dengue fever epidemics has increased dramatically, hyperendemic … Hagiya H, Okita S, Kuroe Y, et al; A fatal case of streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. Introduction. Figure 4: Patients with dengue hemorrhagic fever Complications include dengue hemorrhagic fever, which if left untreated, most likely progresses to dengue shock syndrome. Intermittent high-grade fever accompanied by chills and rigors is a feature. Dengue shock syndrome is said to be the most serious form of dengue infection. Clinicians should therefore be aware of their clinical features, laboratory diagnosis and clinical management. Severe dengue . Dengue virus is transmitted by female mosquitoes mainly of the species Aedes aegypti and, to a lesser extent, Ae. Severe dengue . Patients with DHF (dengue haemorrhagic fever) or DSS (Dengue shock syndrome) may have a range of outcomes, depending upon their condition and how quickly treatment has been provided. Dengue shock syndrome (DSS), seen primarily in children, is the most serious life-threatening manifestation. albopictus for DENV. Dengue (cont…) Dengue haemorrhagic fever and shock syndrome appear most often in patients previously infected by a different serotype of dengue, thus suggesting an immunopathological mechanism. In Thailand, dengue infection is … Treatment is supportive. organs with a possible 20% mortality rate (Ostronoff et al. In less than 5% of the cases, Dengue fever may develop into dengue hemorrhagic fever or dengue shock syndrome, both of which can be life-threatening. Mortality … Aedes aegypti (Linnaeus) (Diptera: Culicidae) is the main vector of dengue viruses (serotypes 1–4), responsible for dengue fever, dengue shock syndrome, and dengue haemorrhagic fever, which are endemic diseases throughout tropical and subtropical countries. Pulse pressure drop to ≤ 20mm Hg with peripheral vascular collapse suggest Dengue shock Syndrome while delayed capillary refill, rapid heart rate or … An epidemic of dengue fever occurred in Delhi which started in the middle of August 1996. A 12-year-old boy who suffering from Dengue Shock Syndrome and had presented with no pulse and no blood pressure at the time of admission was successfully operated upon. Brain, Humans, Child Abuse, Male, Infant, and 3 more Siblings, Shaken Baby Syndrome, and X ray Computed Tomography ( Siblings , Shaken Baby Syndrome , and X ray Computed Tomography ) Aggressive management of dengue shock syndrome may decrease mortality rate: A … Sciences for the Developing World. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash. Fatality rates among patients with DSS can be 10% or higher but, with early recognition and treatment, can be less than 1%. albopictus.These mosquitoes are … Crystalloid fluid resuscitation and standard DIC treatment are critical to the child's survival. The (A) body weight (B) clinical score and (C) survival rate were monitored daily after inoculation. The diagnosis generally made after the patients have presented with severe dengue symptoms. The case fatality rate for DHF has been increasing this year (2005). ... , Dengue hemorrhagic fever, Dengue shock syndrome. Some proportion of cases develop the life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome characterized by Shock. While this rate may seem low, worldwide it means that about 500,000 to 1 million people die each year from dengue fever. survival rate and nausea and vomiting show greater hazard for DSS patients whereas petechlae and abdominal pain were also significant in predicting the survival rate in DF (Dengue Fever). Dengue is an important mosquito-borne human viral disease globally. Consequently, we analyzed the extent to which two blood sources affected life table characteristics (i.e. This study is a retrospective analysis that covers the last 14 years (2006–2019) of reported dengue cases from Epidemiology Diseases … Background: Dengue virus infection is an important mosquito-borne disease with the reported 40,000-100,000 cases per year in Thailand. This unique volume presents an up-to-date review of one of the world's major health problems — diseases caused by the four dengue viruses. Mortality Depending upon the host’ s resistance and possibly the viral virulence, shock syndrome, if not managed, can prove terminal (irreversible). Kan EF, Rampengan TH. 2003). Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Two patients who had dengue haemorrhagic fever survived. Sciences for the Developing World. Dengue fever (DF) can cause a wide spectrum of presentations ranging from uncomplicated self-limiting febrile illness to severe dengue including dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). We conducted a cross-sectional study to investigate the clinical factors associated with mortality in Patients with dengue viral infection at a tertiary care center over a 3 year period. Dengue and Zika Virus Epidemiology and Clinical Manifestations. Although most symptomatic dengue infections follow an uncomplicated course, complications and unusual manifes-tations are increasingly being reported due to rising burden hemorrhagic manifestations and refractory shock. It presents with acute onset of fever with nonspecific constitutional symptoms and signs of hemorrhagic diathesis, which may progress to fatal shock (Dengue shock syndrome, DSS). Prognosis • Dengue fever < 1% mortality • Dengue hemorrhagic fever approx 2.5% mortality • Primarily children • Dengue shock up to 47% mortality DHF and DSS symptoms include fever; a low platelet count; haemorrhagic bleeding and vascular permeability. The co-circulation of dengue virus serotypes 1, 2, and 4 in the Caribbean facilitates the development of dengue shock syndrome (DSS) or dengue haemorrhagic fever (DHF). -dengue is contagious person to person-DHF is a pediatric disease -Dengue + bleeding = DHF => need 4 who criteria, cap perm-DHF kills only by hemorrhage -> pt dies as result of shock-Poor management turns dengue into DHF => poorly managed dengue can be more severe but DHF is a distinct condition which even well-treated pt may develop Access Dengue shock syndrome national notifiable time periods and case definitions. NOTICE: The National Notifiable Diseases Surveillance System … The Kaplan-Meier survival analysis is based on the total survival days in the period from hospitalization to discharge among patients with dengue fever (DF) or dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) in the renal failure (RF) group and in the non-RF group. We conducted this study to evaluate the shock index (SI) for this issue. The nature, structure and biology of the four dengue viruses are described, and a major portion of the book is focused on the epidemiology of dengue … The definition of dengue shock syndrome follows all of the above criteria for dengue hemorrhagic fever and also includes hypotension or narrow pulse pressure (less than or equal to 20 mm Hg). We analyzed Taiwanese medical data from the Registry of the National Notifiable Disease Reporting System of Taiwan’s Centers for Disease … Dengue shock syndrome: A syndrome due to the dengue virus that tends to affect children under 10, causing abdominal pain, hemorrhage (bleeding) and circulatory collapse (shock).Known also as dengue hemorrhagic fever (DHF), it starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat, cough, nausea, vomiting, and … Genomic DNA was obtained from 194 patients. Keywords: Dengue, Aedes Aegypti, Dengue hemorrhagic fever, Hemorrhagic shock syndrome, Genetic susceptibility, Vaccine development Background Dengue fever is a major cause of illness and death worldwide. THOMAS P. MONATH. Dengue shock syndrome can present with refractory hypotension, large pleural e usion, ascites, and even pulmonary edema. Acute pain related to abdominal pain and severe headaches as evidenced by pain scale rating of 9/10, guarding behavior, and abnormal vital signs secondary to dengue shock syndrome Prognosis The prognosis for dengue is usually good. 85% of the Dengue fever patients didn’t fulfill the criteria for hospital admission where rest … The latter half of the 20th century has seen the emergence of dengue as one of the principal infectious diseases of the tropical world [].At present, some 2.5 billion people live in areas of risk, between 250 and 500,000 cases of dengue hemorrhagic fever (DHF) are reported to the World Health Organization (WHO) annually, and an estimated 100 million cases of dengue fever (DF) occur … DHF is sometimes associated with severe shock syndrome caused Early resuscitation of dengue shock syndrome in children with hyperosmolar sodium-lactate: a randomized single-blind clinical trial of efficacy and safety. DISCUSSION Septic shock … Dengue Shock Syndrome (DSS) — Shock syndrome is a dangerous complication of dengue infection and is associated with high mortality. The virus responsible for causing dengue, is called dengue virus (DENV). Dengue virus (DENV) is the cause of dengue fever.It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. Dengue is the most widely distributed mosquito-borne viral infection of humans, affecting an estimated 100 million people worldwide each year. Among them 30 patients had Dengue fever, 52 patients had Dengue Hemorrhagic fever, 8 patients had Dengue Shock Syndrome. Shock is the primary evidence in DHF, while other organs’ involvement is secondary to shock. Brain, Humans, Child Abuse, Male, Infant, and 3 more Siblings, Shaken Baby Syndrome, and X ray Computed Tomography ( Siblings , Shaken Baby Syndrome , and X ray Computed Tomography ) Aggressive management of dengue shock syndrome may decrease mortality rate: A … The number of symptomatic dengue infections has doubled every 10 y since 1990, in contrast to the declining incidence of most other com-municable diseases (3). Andreset al, 2011, Epidemiological Factors Associated with Dengue Shock Syndrome and Mortality in Hospitalized Dengue Patients in Ho Chi Minh City, Vietnam. Korman TM, Boers A, Gooding TM, et al; Fatal case of toxic shock-like syndrome due to group C streptococcus associated with superantigen exotoxin.J Clin Microbiol. In humans, dengue infection causes a spectrum of illnesses ranging from asymptomatic, fever, rash, joint pain and other mild symptoms to life-threatening dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) . J Trop Pediatr 2011;57:451-6. (a) classical dengue fever (DF); (b) dengue haemorrhagic fever (DHF); and (c) dengue shock syndrome (DSS), according to the WHO criteria[9]. There are many people who carry the virus Yellow fever: Yellow fever. Only small percentage of individuals progress to life-threatening dengue, dengue hemorrhagic fever, and dengue-shock syndrome, featured with … The DALYs for each age-specific category and degree of severity were multiplied by the number of cases in each year and then summed to give annual totals. Virus serotype DEN-2 was found to be responsible for this outbreak. An overwhelming 75 – 90% of patients acquire dengue fever … In its absence, the case fatality rate can be has high at 20% in patients with severe dengue. The spectrum of clinical disease is broad. The first recorded epidemic of dengue was reported in the late 18thcentury and affected Asia, Africa, and North America. fecundity, fertility, hatch rate, adult survival) and vector competence (infection, dissemination, transmission) of Ae. Dengue is one of the newest emerging diseases in Nepal with increasing burden and geographic spread over the years. Ninety percent of DHF subjects are children less than 15 years of age. Author summary Dengue is a very common, potentially serious, mosquito-borne viral infection. Dengue viral infections are one of the most important mosquito borne diseases in the world. Dengue is an infectious disease caused by female mosquito AEDES AEGYPTI. The propagation of the virus appears to be dependent on human populations with a sufficient number of susceptible members to support infection (Ehrenkranz et al., 1971). There are four DENV serotypes, meaning that it is possible to be infected four times. How to Prevent Dengue Fever. The first dengue vaccine, Dengvaxia (CYD-TDV) by Sanofi Pasteur, was first licensed in December, 2015, in Mexico. Dengue and Zika viruses are transmitted by Aedes species mosquitoes, primarily Aedes aegypti, which are present throughout the tropics and subtropics (1,2). This study is a retrospective analysis that covers the last 14 years (2006–2019) of reported dengue cases from Epidemiology Diseases … Although it resolves spontaneously in most cases, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are among the leading causes of pediatric hospitalization. ... (shortened platelet survival time). Dengue classically presents with high fever, headache, body aches, exanthem, and generalized lymphadenopathy. During epidemics, most infections cause an acute but self-limited febrile illness with complete recovery. Description. Despite the high rate of dengue 1 infections in 1980, only dengue 2 viruses were recovered from dengue shock syndrome cases, including two dengue 1 immune children with pre-illness serum specimens. PDF | Dengue fever is the most important mosquito-borne viral disease in Southeast Asia. Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are among the leading causes of pediatric hospitalization in Asia, with up to 500,000 cases reported annually to the World Health Organization (WHO) [4]. Dengue fever is a common mosquito-borne illness in many tropical and subtropical countries. Fluid resuscitation is critical with added support for failing organs [ 3 ]. DENGUE IN THE CONTEXT OF THE IMCI i Dengue, Dengue Haemorrhagic Fever and Dengue Shock Syndrome in the Context of the Integrated Management of Childhood Illness Department of Child and Adolescent Health and Development DISCUSSION PAPERS ON CHILD HEALTH DENGUE IN THE CONTEXT OF THE IMCI CAH WHO/FCH/CAH/05.13 Overall, the fatality rate is about 1% for all dengue fever infections. Factors associated with shock in children with dengue hemorrhagic fever. We report a rare case of hemorrhagic encephalopathy in dengue shock syndrome caused by type 3 dengue virus. ‘Dengue complications are often termed dengue shock syndrome and is also associated with high mortality rate. Consensus on management of complicated cases of dengue infection is evolving. Mild dengue fever causes a high fever and flu-like symptoms. Disease Name: • Dengue, dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS) s New WHO classification categorizes dengue into dengue, with and without warning signs, and severe dengue, rather than DHF and DSS DISCUSSION Septic shock despite being uncommon, is … Admission characteristics of 48 children with dengue shock syndrome, presented according to severity of shock as assessed at discharge or death. The mosquito vector is the same that carries the Yellow fever virus. Female mosquitoes, predominantly of the species Aedesaegyptiand less commonly, Aedesalbopictus,are responsible for the transmission of the dengue virus. Among the 52,935 residents of the study area, there were 22 cases of virologically and clinically confirmed dengue shock syndrome, in children 15 years or younger. All 22 shock syndrome cases had secondary type antibody responses. Dengue and dengue hemorrhagic fever (DHF) are caused by one of falicivirus. ISBN: 978-1-908978-79-0 (ebook) Checkout. A retrospective case–control study was conducted by recruiting older patients (≥ 65 years old) with DF who visited the study hospital in southern Taiwan during the 2015 DF outbreak. Dengue is transmitted via the bite of mosquitoes that carry the viruses. Box plots showing levels of specific coagulation proteins among 167 Vietnamese children with dengue shock syndrome, according to the day of sampling, where day 1 is the day of admission to the hospital with dengue shock syndrome. Hyg., 84 (1), pp.127-134. It can be caused by four different strains of the same virus (DEN-1 to DEN-4). During epidemics of dengue, attack rates among susceptible are 40-90% (Chaturvediet al., 2004). “ Dengue haemorrhagic fever (DHF), a potentially lethal complication, was first recognized in the 1950s during the dengue epidemics in the Philippines and Thailand, but today DHF affects most Asian countries and has become a leading cause of hospitalisation and death among children in several of them. About 33% of DHF patients will develop circulatory failure, also known as dengue shock syndrome (DSS), which has a mortality rate of 12%-44% (Meltzer et al 1998). Six hundred ninety-nine Patients with a clinical diagnosis of dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) during the study period were included in the study. Dengue; Dengue fever; Dengue hemorrhagic fever (DHF) Dengue shock syndrome; Dental and Craniofacial Research, National Inst. During this epidemic, 98 adult patients diagnosed to have dengue haemorrhagic fever (DHF) (n=75) and dengue shock syndrome (DS) (n=23) were admitted to one of the medical units of the The disease burden of dengue has been steadily rising over the last half-century due to a multitude of factors, including global trade and travel, urbanization, population growth, and climate variability and change, that facilitate conductive conditions for the proliferation of dengue vectors and viruses. Departemen Kesehatan RI, 2004, Tata Laksana Demam Berdarah Dengue di Indonesia. The severe form of dengue fever, also called dengue hemorrhagic fever, can cause serious bleeding, a sudden drop in blood pressure (shock) and death. Dengue is primarily a disease of the tropics, and the viruses that cause it are maintained in a cycle that involves humans and Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans. number makes a diagnosis of dengue more likely with the cut off being more than 10 to 20 per 1 inch2 2(6.25 cm ). (D) The mice were sacrificed at day 5 p.i. Dengue shock syndrome: Four (4) criteria for DHF High grade fever Hemorrhagic manifestations Low platelet count Evidence of plasma leakage Plus Evidence of circulatory failure manifested indirectly by: Rapid and weak pulse, Delayed perfusion. The main objective of this study was to explore the epidemiological patterns of dengue since its first outbreak (2006) to 2019 in Nepal. The statistical analysis was done using the … Patients with grade III hemorrhagic shock (who fulfilled at least 2 of these following criteria: 1.5-2 L blood loss estimation, MAP <65 mmHg, pulse pressure <20 mmHg, heart rate >120 times/min, respiratory rate 30-40 times/min or urinary output 5-15 ml/hour) due to multiple injuries (simultaneously injuries in two or more organs of the body) The mortality rate in Dengue Shock Syndrome ranges from 6 to 30 percent, most commonly reported in children. Some cases progress to the more severe dengue hemorrhagic fever (DHF) with thrombocytopenia, spontaneous bleeding, and potentially shock (dengue shock syndrome). DHF and DSS can occur in both children and adults. The Kaplan-Meier survival analysis is based on the total survival days in the period from hospitalization to discharge among patients with dengue fever (DF) or dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) in the renal failure (RF) group and in the non-RF group. Prevention of dengue in endemic areas depends on mosquito eradication. The brain tissues were cryosectioned and DV2-NS1 expression in various … Infection with any of these viruses can result in an acute illness that includes fever, rash, myalgia, and arthralgia. Dengue fever is usually caused by 4 distinct serotypes (DEN1, DEN2, DEN3, and DEN4). Older adults have a higher mortality for dengue fever (DF). Patients with dengue can rapidly progress into DSS, which, if not treated correctly, can lead to severe complications and death. Pediatr Indones 2004;44:171-5. The symptoms of dengue hemorrhagic fever can trigger dengue shock syndrome. For example, DHF and DSS have about 50% fatality rate if untreated but only about a 3% rate if treated with supportive measures. Dengue virus has four related but antigenically distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4 [].The global burden of dengue has increased in recent decades causing huge impact on both human health and the national economics [1,2,3] .Dengue infection has a diverse clinical presentation ranging from … Dengue shock syndrome is severe, and can lead to excessive bleeding and even death. Dengue is the most frequent mosquito-borne viral infection among human beings, with more than 50 million new infections being projected annually [1]. Dengue shock syndrome is severe, and can lead to excessive bleeding and even death. Dengue-2 virus infection induces physiopathological changes of the ICR mice. Dynamic clinical presentations in affected subjects have been well documented. [3] According to the experts, 3.5 billion people across the world are at risk of dengue viral infection which is spreading increasingly with growing rates of urbanization. An estimated 2.5 billion people live in areas where they are at risk of becoming infected with dengue virus. dengue shock syndrome, metabolic acidosis, unremitting haemorrhage and multi-organ failure, which may be ... lead to septic shock which carries a mortality rate of about 1 in 3 (31%) (2). Dengue hemorrhagic fever (DHF) occasionally progress to fulminant liver failure with high fatality rate. Dengue fever also has a characteristic skin rash that looks similar to measles. [2,3,5] This complication can further deteriorate into dengue shock syndrome. Dengue infection is a systemic and dynamic disease transmitted between humans by Aedes mosquitoes [3,4], and it ranges widely in the clinical spectrum from asymptomatic or self-limiting to severe clinical manifestations. Dengue shock syndrome can lead to … It is endemic in parts of Asia and the Americas and has been increasingly reported from many tropical countries in recent years [1–3]. Mosquito. Severe dengue is a leading cause of serious illness and death in some Asian and Latin American countries. Dengue fever, Dengue Hemorrhagic fever, Dengue shock syndrome- The 2009 clinical diagnosis involves: Dengue fever without warning signs; Fever and two of the following: nausea and vomiting, rash, aches and pains, leukopenia, and positive tourniquet test (capillary fragility test: place blood pressure cuff on patient. A child with dengue hemorrhagic fever or dengue shock syndrome may present severely hypotensive with disseminated intravascular coagulation (DIC), as this severely ill PICU patient did. The presence of a warning sign may predict severe dengue in a patient. Two variants exist – dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). A child with dengue hemorrhagic fever or dengue shock syndrome may present severely hypotensive with disseminated intravascular coagulation (DIC), as this severely ill pediatric ICU patient did. Two variants exist – dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). † DHF and dengue shock syndrome are primarily dis-eases of children and are thought to occur in persons previously infected with another serotype of dengue. Infection with dengue virus results in various conditions like pathological ranging from mild asymptomatic dengue fever to severe dengue hemorrhagic fever and dengue shock syndrome that causes to death Dengue fever is typically a self-limited disease with a mortality rate of less than 1% when detected early and with access to proper medical care. Prognosis • Dengue fever < 1% mortality • Dengue hemorrhagic fever approx 2.5% mortality • Primarily children • Dengue shock up to 47% mortality Inadvertent use of blood products to control massive bleeding in dengue shock syndrome may worsen fluid overload and subsequently the multi-organ dysfunction. The epidemiological triangle of DF Severe forms include dengue shock syndrome, dengue haemorrhagic fever and dengue shock syndrome, all of which are potentially lethal. Risk factors of dengue shock syndrome in children. No specific antiviral therapy is available. The clinical manifestations of DENV infection range from an asymptomatic infection to a debilitating but self-limited illness termed dengue fever (DF), to more severe forms of the disease characterized by increased vascular permeability and plasma leakage, known as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) [2, 3]. ... had a severe consequence on his chance of survival. Dengue shock syndrome (DSS) is a severe complication of dengue hemorrhagic fever (DHF) and can lead to death, but DSS incidence and effects are difficult to predict via clinical examination. dengue shock syndrome, metabolic acidosis, unremitting haemorrhage and multi-organ failure, which may be ... lead to septic shock which carries a mortality rate of about 1 in 3 (31%) (2). Crit Care. competence for dengue virus (DENV) is unknown. deadly dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) because of the severity of antibody response (Valdes et al., 2000). Among them 30 patients had Dengue fever, 52 patients had Dengue Hemorrhagic fever, 8 patients had Dengue Shock Syndrome. haemorrhagic fever (DHF) and Dengue shock syndrome (DSS) and about 30,000 deaths (Guzmán et al., 2002). One study estimated that 50 million infections occur every year. The WHO case definitions for dengue shock are shown in Box 1. However, if adequate treatment is provided, dengue fever is not a fatal disease with a fatality rate of less than 1%. A total of 90 Dengue patients were included in the study. rate, dangerously low blood pressure, fluid accumulation, low levels of blood platelets, and blood plasma leakage, and more). Symptoms usually subside within one week. Dengue virus has four related but antigenically distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4 [].The global burden of dengue has increased in recent decades causing huge impact on both human health and the national economics [1,2,3] .Dengue infection has a diverse clinical presentation ranging from …
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